Related Experiment Video

Updated: Feb 12, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
11:50

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

27.8K

Conjugated Hyperbilirubinemia in the Neonate and Young Infant

Anna K Weiss1, Parag V Vora

  • 1Assistant Professor of Clinical Pediatrics (Weiss), Perelman School of Medicine at the University of Pennsylvania; Attending Physician (Weiss), Division of Emergency Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; and Attending Physician (Vora), Pediatric Emergency Medicine, Envision Physician Services, Capital Health Medical Center, Pennington, NJ.

Pediatric Emergency Care
|March 31, 2018
PubMed

Insights

Neonatal cholestasis, or jaundice in newborns, can signal serious illness. Pediatricians must suspect severe conditions and investigate promptly to diagnose and manage this critical condition effectively.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Hepatology

Background:

  • Cholestatic jaundice in newborns presents a diagnostic challenge.
  • Early identification is crucial due to potential life-threatening causes.
  • Requires a high index of suspicion from pediatric practitioners.

Purpose of the Study:

  • To outline the epidemiology of neonatal cholestasis.
  • To describe the pathophysiology of cholestatic jaundice in infants.
  • To detail the differential diagnosis and diagnostic workup for neonatal cholestasis.

Main Methods:

  • Review of epidemiological data on neonatal cholestasis.
  • Analysis of pathophysiological mechanisms.
  • Compilation of differential diagnoses and recommended diagnostic pathways.

Main Results:

  • Identifies common and severe causes of neonatal cholestasis.
  • Provides a framework for systematic investigation.
  • Highlights the importance of early suspicion and workup.

Conclusions:

  • Prompt and thorough investigation is essential for managing neonatal cholestasis.
  • Understanding the differential diagnosis aids in timely and accurate diagnosis.
  • Effective management strategies depend on early detection of severe underlying pathology.

More Related Videos

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.1K
How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children07:27

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

12.6K

Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
29.0K
Conjugated Proteins02:50

Conjugated Proteins

3.2K
Conjugation01:19

Conjugation

Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...
2.5K
Mechanism of Conjugation01:19

Mechanism of Conjugation

Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
1.1K
Relative Strengths of Conjugate Acid-Base Pairs02:29

Relative Strengths of Conjugate Acid-Base Pairs

Brønsted-Lowry acid-base chemistry is the transfer of protons; thus, logic suggests a relation between the relative strengths of conjugate acid-base pairs. The strength of an acid or base is quantified in its ionization constant, Ka or Kb, which represents the extent of the acid or base ionization reaction. For the conjugate acid-base pair HA / A−, the ionization equilibrium equations and ionization constant expressions are
52.7K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
324