Role of prostaglandins in human reproduction: recent advances

Our knowledge of the importance of PGs for the physiological regulation of male and female reproductive organs is rapidly increasing. In this presentation two examples have been described in detail. Data are accumulating indicating that PGs in semen are of major importance for sperm motility and the functional capacity of sperms. Recording of intrauterine pressure in early pregnant patients has shown that treatment with an antiprogestin depriving the myometrium from progesterone influence, will induce regular uterine contractions. The data support the hypothesis that the uterine activity is regulated by the balance between PGF2 alpha and progesterone.