Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmaceutical Equivalents

Pharmaceutical Equivalents

As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

Pharmaceutical Poisoning: Treatment Strategies

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Associations between older adults' attitudes to ageing, mental health, and quality of life: a systematic review.

European journal of ageing·2026

Same author

Real-World Patient Characteristics, Mutational Landscape, and Outcomes in Advanced/Metastatic <i>HER2</i>-Mutant Non-Small Cell Lung Cancer.

JCO precision oncology·2026

Same author

A novel CRLF2-targeted antibody-drug conjugate exhibits potent anti-leukemic activity against Ph-like acute lymphoblastic leukemia.

Leukemia·2026

Same author

Post-COVID-19 Burden of Severe Influenza in England Among Overall Population and High-Risk Groups: Results From the INFORM Study, 2022-2023.

Infectious diseases and therapy·2026

Same author

Disparities in Recombinant Zoster Vaccine Coverage in the United States.

Population health management·2025

Same author

Healthcare Utilization and Cost in the Two Years Before Neuromodulation Implantation Among Medicaid Enrollees with Drug-Resistant Epilepsy.

ClinicoEconomics and outcomes research : CEOR·2025

Search research articles

Related Experiment Video

Updated: Feb 12, 2026

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

Pharmaceutical Waste: A Checklist For Compliance.

Provider (Washington, D.C.)

|March 31, 2018

Summary

This summary is machine-generated.

Improper drug disposal poses environmental risks and can lead to significant penalties for healthcare facilities. Proper waste management is crucial for compliance and environmental protection.

More Related Videos

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Published on: April 26, 2024

Author Spotlight: Advancing Anaerobic Microbiota Research Using a Novel Respirometry Protocol

Author Spotlight: Advancing Anaerobic Microbiota Research Using a Novel Respirometry Protocol

Published on: April 26, 2024

Related Experiment Videos

Last Updated: Feb 12, 2026

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Author Spotlight: Improved Imaging for Neovascular Development in Congenital Heart Disease Research

Published on: April 26, 2024

Author Spotlight: Advancing Anaerobic Microbiota Research Using a Novel Respirometry Protocol

Author Spotlight: Advancing Anaerobic Microbiota Research Using a Novel Respirometry Protocol

Published on: April 26, 2024

Area of Science:

Environmental Science
Health Policy

Background:

Improper disposal of pharmaceutical waste presents a significant environmental hazard.
Non-compliance with drug disposal regulations can result in severe financial penalties for healthcare organizations.

Purpose of the Study:

To highlight the environmental risks associated with incorrect drug disposal.
To emphasize the potential for substantial financial penalties for centers that do not adhere to proper disposal protocols.

Main Methods:

Review of environmental regulations pertaining to pharmaceutical waste.
Analysis of case studies on penalties incurred due to improper drug disposal.

Main Results:

Pharmaceuticals in the environment can contaminate water sources and harm ecosystems.
Failure to comply with disposal guidelines can lead to fines ranging from thousands to millions of dollars.

Conclusions:

Adherence to proper drug disposal practices is essential for environmental stewardship.
Implementing robust pharmaceutical waste management systems is critical for mitigating legal and financial risks.