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Optimizing outcomes with polymethylmethacrylate fillers.

Michael H Gold1, Neil S Sadick2

  • 1Gold Skin Care Center, Nashville, TN, USA.

Journal of Cosmetic Dermatology
|March 31, 2018
PubMed
Summary
This summary is machine-generated.

Bellafill, a polymethyl methacrylate (PMMA) filler, shows a strong safety and effectiveness profile over 10 years of post-marketing surveillance. Proper technique is crucial for optimal outcomes with this long-lasting dermal filler.

Keywords:
Artecollbellafilldermal implantgranulomamicrospheressoft tissue augmentation

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Area of Science:

  • Dermatology
  • Plastic Surgery
  • Biomaterials Science

Background:

  • The ideal dermal filler should be long-lasting, biocompatible, and safe.
  • This review examines Bellafill (polymethyl methacrylate-collagen gel), its development, and 10 years of post-marketing data.
  • Bellafill was initially approved by the FDA as Artefill in 2006 and rebranded in 2015.

Purpose of the Study:

  • To review the evolution and development of polymethyl methacrylate (PMMA) fillers, specifically Bellafill.
  • To evaluate the efficacy and safety of Bellafill based on 10 years of post-marketing surveillance.
  • To compare Bellafill with other PMMA fillers regarding safety and adverse events.

Main Methods:

  • Literature search on PubMed for articles on Arteplast and Bellafill development.
  • Analysis of post-marketing surveillance data for Bellafill from 2007-2016.
  • Evaluation of factors influencing efficacy and safety of major PMMA fillers globally.

Main Results:

  • Bellafill manufacturing and purification processes minimize adverse events.
  • Over 530,000 Bellafill syringes distributed showed only 11 confirmed granulomas (0.002%).
  • Adverse events with PMMA fillers are often linked to technique, not solely product quality.

Conclusions:

  • Bellafill demonstrates an excellent safety and effectiveness profile supported by clinical studies and post-marketing data.
  • Injector skill and technique are critical for achieving optimal outcomes with Bellafill.
  • While adverse events can occur with any filler, Bellafill's profile is strong when used correctly.