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Updated: Feb 12, 2026

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Perspectives on Neuroscience
Published on: July 31, 2007
5.4K
DARK Classics in Chemical Neuroscience: Methamphetamine.
Thomas J Abbruscato1, Paul C Trippier1
1Department of Pharmaceutical Sciences, School of Pharmacy , Texas Tech University Health Sciences Center , Amarillo , Texas 79106 , United States.
ACS Chemical Neuroscience
|April 1, 2018
Summary
Methamphetamine abuse affects 35 million globally. This review covers the synthesis, pharmacology, and effects of (S)-(+)-methamphetamine, a potent psychostimulant.
Area of Science:
- Neuroscience
- Pharmacology
- Organic Chemistry
Background:
- Methamphetamine is the second most abused drug globally, with 35 million users.
- (S)-(+)-methamphetamine is the illicit, neurostimulant enantiomer, distinct from the (R)-(-)-enantiomer found in decongestants.
- Prescription use for ADHD and obesity contrasts with its widespread illicit abuse.
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