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Related Experiment Videos

A sonographic screening method for Down syndrome.

C Lockwood1, B Benacerraf, A Krinsky

  • 1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.

American Journal of Obstetrics and Gynecology
|October 1, 1987
PubMed
Summary

This study introduces a new screening method for Down syndrome detection using ultrasound biometry. The biparietal diameter/femur length ratio shows promise for identifying fetuses with Down syndrome in the second trimester.

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Area of Science:

  • Prenatal Diagnostics
  • Fetal Ultrasound
  • Medical Genetics

Background:

  • Second-trimester screening for fetal Down syndrome is crucial for timely intervention.
  • Current screening methods have limitations in sensitivity and specificity.

Purpose of the Study:

  • To evaluate the biparietal diameter/femur length ratio as a potential sonographic screening marker for fetal Down syndrome in the second trimester.

Main Methods:

  • Retrospective analysis of biparietal diameter, femur length, and their ratio in 55 fetuses with Down syndrome and 544 controls.
  • Data assessed between 15 to 23 weeks' gestation across two medical centers.

Main Results:

  • Fetuses with Down syndrome showed no significant difference in cephalic index or biparietal diameter.

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  • Significant femur length shortening was observed in Down syndrome fetuses.
  • The biparietal diameter/femur length ratio was consistently elevated in fetuses with Down syndrome compared to controls.

    • Conclusions:

    • The biparietal diameter/femur length ratio may be a superior screening marker for Down syndrome.
    • This ratio can potentially enhance the sensitivity and specificity of existing screening modalities.