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Direct Drug Delivery to Kidney via the Renal Artery
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A Systems-Level View of Renal Metabolomics
1Nephrology and Endocrinology Divisions, Massachusetts General Hospital, Boston, MA.
Seminars in Nephrology
|April 1, 2018
Summary
Kidney disease alters numerous blood metabolites, some with functional roles in complex interorgan circuits. Understanding these systemic effects is key for identifying new biomarkers and treatments in nephrology research.
Area of Science:
- Nephrology
- Metabolomics
- Systems Physiology
Background:
- Circulating metabolites like creatinine, glucose, and cholesterol are vital in clinical medicine.
- Metabolomics in nephrology aims to discover novel biomarkers for kidney disease and its complications.
- Established physiological principles guide current metabolomic research.
Purpose of the Study:
- To review three key themes in renal metabolomics.
- To highlight the kidney's broad impact on circulating metabolites.
- To emphasize a systems-level approach for understanding renal metabolomics.
Main Methods:
- Review of established physiological principles.
- Integration of recent metabolomic and other technological advancements.
- Analysis of metabolite alterations in progressive kidney disease.
Main Results:
- The kidney significantly impacts circulating metabolites, with function loss causing widespread small molecule changes.
- Emerging evidence shows functional roles for metabolites, including as G-protein-coupled receptor ligands.
- Metabolites engage in complex interorgan trafficking pathways.
Conclusions:
- Viewing renal metabolomics at a systems level is crucial.
- Recognizing diverse origins and physiological effects of blood metabolites is important.
- Further research is needed to synthesize these themes and establish clinical relevance.
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