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[Tropical endomyocardial fibrosis: Perspectives].

M Lachaud1, C Lachaud2, D Sidi3

  • 1Thorax Institute, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France; Service de Cardiologie pédiatrique, Centre Hospitalier Universitaire de Sainte Justine, Montréal, Québec, Canada; Instituto do Coraçao, 1111, avenue Kenneth-Kaunda, Maputo, Mozambique.

Annales De Cardiologie Et D'Angeiologie
|April 1, 2018
PubMed
Summary

Tropical endomyocardial fibrosis (FET) is a major cause of heart failure and restrictive cardiomyopathy globally. Understanding its unclear origins and improving diagnostics are key to better patient outcomes.

Keywords:
AfricaAfriqueCardiopathie restrictiveCassavaEndomyocardial fibrosisEosinophileEosinophiliaFibrose endomyocardiqueManiocRestrictive cardiomyopathy

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Area of Science:

  • Cardiology
  • Tropical Medicine
  • Pathology

Background:

  • Tropical endomyocardial fibrosis (FET) is a primary cause of heart failure and the most prevalent restrictive cardiomyopathy worldwide.
  • The condition is characterized by extensive ventricular endocardial fibrosis, leading to architectural distortion, impaired cardiac filling, and valvular insufficiency.
  • FET is geographically restricted, with an obscure etiology and a poor prognosis.

Purpose of the Study:

  • To review the current understanding of tropical endomyocardial fibrosis (FET).
  • To highlight recent changes in disease burden and advancements in diagnostic tools.
  • To explore alternative approaches for disease comprehension and therapeutic strategies.

Main Methods:

  • Literature review of studies on tropical endomyocardial fibrosis.
  • Analysis of recent epidemiological data from endemic areas.
  • Evaluation of emerging diagnostic techniques.

Main Results:

  • Recent reports indicate a changing disease burden in some endemic regions.
  • Refined diagnostic tools are becoming available for FET.
  • The etiology of FET remains largely unknown.

Conclusions:

  • Despite challenges, advancements in diagnostics and evolving epidemiological data offer new avenues for FET research.
  • Further investigation into the etiology and improved diagnostic capabilities are crucial for developing effective treatments.
  • A better understanding of FET is essential for improving the grim prognosis associated with this condition.