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Related Experiment Video

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Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates
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The non-human primate kidney transcriptome in fetal development.

Kimberly D Spradling-Reeves1, Jeremy P Glenn2, Kenneth J Lange3

  • 1Department of Internal Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

Journal of Medical Primatology
|April 1, 2018
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Summary

This study reveals novel gene expression patterns in developing primate kidneys. Findings highlight discordant gene splice variants, emphasizing the need for further proteomic research in fetal kidney development.

Keywords:
arraybabooncluster analysisgene expressionontogenypathway analysis

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Area of Science:

  • Developmental Biology
  • Genomics
  • Nephrology

Background:

  • Limited understanding of non-human primate kidney gene expression during development.
  • Primate renal transcriptome characterization during fetal development and maturation is needed.

Purpose of the Study:

  • To establish an understanding of the primate renal transcriptome during fetal development.
  • To analyze gene expression in the context of renal maturation.

Main Methods:

  • Baboon kidney transcriptome analysis at multiple fetal gestational days (60, 90, 125, 140, 160 DG) and adulthood.
  • Gene arrays and quantitative reverse transcription PCR (QRT-PCR) for gene expression profiling.
  • Pathway and cluster analyses to identify biological pathways and gene splice variants.

Main Results:

  • Pathway analysis identified previously unreported pathways relevant to kidney development.
  • Cluster analysis revealed gene splice variants with discordant expression profiles throughout development.
  • Detailed genetic analysis of the developing primate kidney was performed.

Conclusions:

  • This study provides the first comprehensive genetic analysis of the developing primate kidney.
  • Discordant expression of gene splice variants suggests gene arrays offer a simplified view.
  • Further investigation into the fetal renal proteome is warranted.