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Updated: Feb 12, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors

Nirmalya Chatterjee1, Dirk Bohmann2

  • 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|April 1, 2018
PubMed

Insights

The interplay between BET proteins and the Nrf2 pathway influences inflammation and cancer. Understanding this crosstalk can lead to improved combination therapies for these diseases.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Immunology

Background:

  • BET proteins (Brd3, Brd4) regulate gene expression in inflammation and cancer.
  • Nrf2 is a key regulator of cellular defense against oxidative stress and xenobiotics.
  • Nrf2 exhibits both anti-inflammatory properties and roles in cancer progression.

Purpose of the Study:

  • To review the discovery and mechanisms of the regulatory interplay between Nrf2 and BET proteins.
  • To discuss the biomedical implications of this Nrf2-BET protein interaction.
  • To explore potential therapeutic strategies based on this crosstalk.

Main Methods:

  • Literature review of studies on Nrf2 and BET protein interactions.
  • Analysis of gene expression regulatory mechanisms.
  • Evaluation of existing and potential drug targets and therapies.

Main Results:

  • Nrf2 and BET proteins are established drug targets with ongoing clinical trials.
  • The interaction between Nrf2 and BET proteins has significant implications for drug efficacy.
  • This crosstalk is currently an overlooked factor in cancer and inflammatory disease treatments.

Conclusions:

  • The regulatory interplay between Nrf2 and BET proteins is crucial in disease pathogenesis.
  • Targeting Nrf2 or BET proteins individually has limitations.
  • Combinatorial strategies targeting both Nrf2 and BET proteins may enhance therapeutic outcomes for cancer and inflammatory diseases.
Keywords:
AMLBET proteinsCOPDNrf2 signalingcancerinflammationoxidative stress

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