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Updated: Feb 12, 2026
10:46
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
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Cerebral capillary flow imaging by wavelength-division-multiplexing swept-source optical Doppler tomography
Wei Chen1, Congwu Du1, Yingtian Pan1
1Biomedical Engineering, Stony Brook University, Stony Brook, New York.
Journal of Biophotonics
|April 1, 2018
Summary
This study introduces wavelength-division-multiplexing optical Doppler tomography (WDM-ODT) to improve cerebral capillary blood flow imaging. WDM-ODT enhances sensitivity and suppresses noise, enabling quantitative imaging in deep brain regions.
Area of Science:
- Biomedical Optics
- Neuroimaging
- Optical Coherence Tomography
Background:
- Swept-source optical coherence tomography (SS-OCT) offers fast imaging but faces limitations in axial resolution and phase noise for deep cerebral capillary blood flow imaging.
- Existing swept-source optical Doppler tomography (SS-ODT) struggles with sensitivity and noise, hindering quantitative analysis in deep cortical vasculature.
Purpose of the Study:
- To develop and validate a novel wavelength-division-multiplexing optical Doppler tomography (WDM-ODT) method.
- To enhance sensitivity and suppress phase noise for quantitative imaging of cerebral capillary blood flow.
- To demonstrate deep cortex imaging capabilities of SS-ODT.
Main Methods:
- Development of the wavelength-division-multiplexing optical Doppler tomography (WDM-ODT) technique, which divides interferograms for improved phase correlation.
- Utilizing WDM-ODT for imaging in flow phantoms and in vivo mouse brain models.
- Comparative analysis of WDM-ODT with spectral-domain ultrahigh-resolution ODT (uODT).
Main Results:
- WDM-ODT significantly suppresses background phase noise.
- Cerebral capillary flow imaging down to 5.6 μm vessel size was achieved.
- SS-ODT demonstrated an extended imaging depth of 1.6 mm in the mouse cortex, surpassing uODT.
Conclusions:
- WDM-ODT effectively enhances sensitivity for cerebral capillary flow imaging.
- This method enables quantitative capillary flow imaging in the deep cortex for the first time.
- SS-ODT provides superior depth penetration for capillary flow imaging compared to uODT.
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