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Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
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Relationship between serum quantitative HBsAg and HBV DNA levels in chronic hepatitis B patients

Na Yang1, Jin Feng1, Taicheng Zhou2

  • 1Department of Clinical Laboratory, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Journal of Medical Virology
|April 1, 2018
PubMed

Insights

Quantitative Hepatitis B surface antigen (HBsAg) levels correlate with Hepatitis B virus (HBV) DNA in HBeAg-positive chronic hepatitis B patients. However, HBsAg is not a reliable surrogate for HBV DNA in HBeAg-negative patients.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Serum Hepatitis B surface antigen (HBsAg) level is increasingly used to predict treatment outcomes in chronic hepatitis B (CHB).
  • Understanding the relationship between quantitative HBsAg and Hepatitis B virus (HBV) DNA levels is crucial for managing CHB patients.

Purpose of the Study:

  • To determine the correlation between quantitative HBsAg and HBV DNA levels in CHB patients.
  • To explore the potential of quantitative HBsAg as a surrogate marker for serum HBV DNA in CHB patients.

Main Methods:

  • Study included 173 CHB patients, divided into Hepatitis B e antigen (HBeAg) positive and negative groups.
  • Quantitative HBsAg and HBV DNA levels were measured.
  • Correlation analysis was performed, with subgroup analysis for HBeAg-negative patients based on age.

Main Results:

  • A positive correlation between HBsAg and HBV DNA was observed in HBeAg-positive patients (r = 0.509, P < 0.001).
  • A poor correlation was found in HBeAg-negative patients (r = 0.176, P = 0.096), with no correlation in younger (<40 years) and a positive correlation in older (>40 years) HBeAg-negative patients.
  • Mean HBsAg titer and Alanine aminotransferase (ALT) levels were significantly higher in the HBeAg-positive group.

Conclusions:

  • Quantitative HBsAg can reflect HBV DNA levels in HBeAg-positive CHB patients.
  • Quantitative HBsAg cannot serve as a surrogate marker for HBV DNA in HBeAg-negative CHB patients.
  • Findings enhance understanding of HBsAg and HBV DNA dynamics and may inform future CHB treatment strategies.

Keywords:
CHB (chronic hepatitis B)HBV (hepatitis B virus)HBsAg (hepatitis B surface antigen)

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