Niclosamide, a Drug with Many (Re)purposes.
Hachemi Kadri1, Olivia A Lambourne1, Youcef Mehellou1
1Cardiff School of Pharmacy and Pharmaceutical Sciences, College of Biomedical and Life Sciences, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK.
Chemmedchem
|April 1, 2018
Summary
Niclosamide, an old tapeworm drug, shows new promise for treating various diseases like cancer and diabetes. Its ability to affect cell signaling pathways makes it a versatile therapeutic candidate.
Area of Science:
- Pharmacology
- Drug Repurposing
- Molecular Biology
Background:
- Niclosamide is an established anthelmintic medication with a long history of use.
- Recent drug repurposing efforts have identified niclosamide as a promising candidate for various non-parasitic diseases.
Purpose of the Study:
- To highlight the diverse therapeutic potential of niclosamide beyond its traditional use.
- To explore the molecular mechanisms underlying niclosamide's broad-spectrum activity.
Main Methods:
- Literature review of drug repurposing screens and mechanistic studies.
- Analysis of niclosamide's effects on mitochondrial phosphorylation and key signaling pathways.
Main Results:
- Niclosamide demonstrates efficacy against Parkinson's disease, diabetes, viral and microbial infections, and cancers.
- The drug's activity is linked to its ability to uncouple mitochondrial phosphorylation.
- Niclosamide modulates critical signaling pathways including Wnt/β-catenin, mTOR, and JAK/STAT3.
Conclusions:
- Niclosamide exhibits significant therapeutic potential across a wide range of diseases.
- Its multifaceted mechanism of action supports its repurposing for novel indications.
- Further research into niclosamide's efficacy and safety in various disease models is warranted.
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