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Bipolar affective disorder in Down's syndrome.

¹St Michael's House, Ballymun, Dublin, Ireland.

The British Journal of Psychiatry : the Journal of Mental Science

|July 1, 1987

Summary

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This study presents a case of bipolar disorder in an individual with Down syndrome, challenging the notion that Down syndrome prevents mania. This finding is significant for understanding mood disorders in this population.

Area of Science:

Psychiatry
Genetics
Neurology

Background:

Down syndrome is a genetic disorder typically associated with intellectual disability and characteristic physical features.
Existing literature suggests a lower incidence of bipolar disorder, particularly mania, in individuals with Down syndrome.

Observation:

A case report details a male patient diagnosed with bipolar affective illness.
The patient was also diagnosed with Down syndrome.

Findings:

This case contradicts previous reports suggesting that Down syndrome precludes the development of mania.
It highlights the possibility of co-occurring mood disorders in individuals with Down syndrome.

Implications:

The findings suggest that individuals with Down syndrome can develop mania, necessitating careful psychiatric evaluation.

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This case broadens the understanding of the phenotypic expression of bipolar disorder in the context of genetic syndromes.

Further research is warranted to explore the prevalence and specific characteristics of bipolar disorder in the Down syndrome population.