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Updated: Feb 12, 2026

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
Published on: August 9, 2019
Circulating CD34+ and CD34+VEGFR2+ progenitor cells are associated with KLOTHO KL-VS polymorphism
Maria Skrzypkowska1, Bartosz Słomiński1, Monika Ryba-Stanisławowska1
1Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.
The KLOTHO KL-VS gene variant is linked to a higher count of crucial blood stem cells and endothelial progenitor cells. This finding may explain its association with longevity and cardiovascular health.
Area of Science:
- Genetics and Molecular Biology
- Cardiovascular Research
- Aging Research
Background:
- The KLOTHO gene regulates endothelial cell function and integrity, with known anti-aging properties.
- The KLOTHO KL-VS variant is associated with human longevity and cardiovascular disease risk.
- Existing mechanisms for KL-VS associations do not focus on CD34+ cell populations.
Purpose of the Study:
- To investigate the influence of the KLOTHO KL-VS polymorphism on CD34+ and CD34+VEGFR2+ cell populations.
- To explore potential mechanisms linking KL-VS to longevity and cardiovascular health via progenitor cells.
Main Methods:
- Analysis of KL-VS polymorphism in 167 Polish subjects.
- Flow cytometry evaluation of whole blood cells.
- Determination of endothelium-associated serum/plasma factors.
Main Results:
- Individuals with at least one KL-VS allele showed increased numbers of CD34+ and CD34+VEGFR2+ cells and their subpopulations.
- This group also had a more favorable lipid profile.
- Elevated VEGF levels and a trend towards decreased vWF and angiotensin II were observed.
Conclusions:
- The KLOTHO KL-VS polymorphism may confer a survival advantage by maintaining a larger population of hematopoietic and endothelial progenitor cells.
- This mechanism could contribute to the observed associations with longevity and reduced cardiovascular disease risk.
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