Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.0K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.0K
Internal Receptors01:31

Internal Receptors

74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

111.4K
Overview
111.4K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.8K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.8K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

132.2K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
132.2K
Types of Receptors: Internal Receptors01:07

Types of Receptors: Internal Receptors

32.7K
Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
32.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electronic structure engineering of molybdenum carbides for efficient water electrolysis.

Chemical communications (Cambridge, England)·2026
Same author

TaxEL: Taxonomy-Enhanced Entity Representation Learning for Biomedical Entity Linking.

IEEE journal of biomedical and health informatics·2026
Same author

3D nanoprinting of metals by spatiotemporally confined hot electrons via multiple-electron excitations in nanocrystals.

Nature communications·2026
Same author

Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation.

Cell reports·2026
Same author

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Dissipation-Shaped Quantum Geometry in Nonlinear Transport.

Physical review letters·2026

Related Experiment Video

Updated: Feb 12, 2026

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures
08:13

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures

Published on: August 2, 2019

6.2K

Metabotropic glutamate receptor trafficking.

Young Ho Suh1, Kai Chang2, Katherine W Roche2

  • 1Department of Biomedical Sciences, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.

Molecular and Cellular Neurosciences
|April 1, 2018
PubMed
Summary

Metabotropic glutamate receptors (mGlu receptors) regulate brain function. This review details how receptor trafficking, influenced by modifications and protein interactions, controls their presence at synapses, impacting neurological and psychiatric disorders.

Keywords:
EndocytosisMetabotropic glutamate receptorsPhosphorylationPost-translational modificationProtein-protein interactionTrafficking

More Related Videos

A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

8.1K
Author Spotlight: Membrane Protein Reconstitution in Synthetic Cells
07:14

Author Spotlight: Membrane Protein Reconstitution in Synthetic Cells

Published on: March 8, 2024

1.7K

Related Experiment Videos

Last Updated: Feb 12, 2026

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures
08:13

An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures

Published on: August 2, 2019

6.2K
A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

8.1K
Author Spotlight: Membrane Protein Reconstitution in Synthetic Cells
07:14

Author Spotlight: Membrane Protein Reconstitution in Synthetic Cells

Published on: March 8, 2024

1.7K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors crucial for modulating neuronal excitability, synaptic transmission, and plasticity in the central nervous system.
  • Receptor trafficking, including surface expression and endocytosis, is a key mechanism controlling excitatory synaptic function by regulating mGlu receptor abundance, desensitization, and signaling.

Purpose of the Study:

  • To review the regulatory mechanisms governing the surface expression and endocytosis of mGlu receptors.
  • To highlight the roles of post-translational modifications and receptor-protein interactions in mGlu receptor trafficking.

Main Methods:

  • Literature review of studies on mGlu receptor trafficking.
  • Focus on post-translational modifications and protein interactions.

Main Results:

  • Surface expression and endocytosis of mGlu receptors are tightly regulated processes.
  • Post-translational modifications and interactions with other proteins significantly influence mGlu receptor trafficking and synaptic localization.

Conclusions:

  • Understanding the precise events that regulate mGlu receptor expression at synapses is essential.
  • This knowledge can contribute to developing novel therapeutic strategies for developmental, neurological, and psychiatric disorders.