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Transdermal immunomodulation: Principles, advances and perspectives.

Zongmin Zhao1, Anvay Ukidve1, Anshuman Dasgupta1

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, United States.

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|April 1, 2018
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Summary
This summary is machine-generated.

This review explores transdermal immunomodulation, using the skin to regulate immune responses for treating diseases like cancer and allergies. It covers delivery methods, challenges, and future directions for skin-based immune therapies.

Keywords:
Autoimmune diseasesCancer vaccineImmune toleranceImmunomodulationInfectious diseasesMicroneedleTransdermal drug deliveryVaccination

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Area of Science:

  • Immunology
  • Dermatology
  • Drug Delivery

Background:

  • The skin's immune cells and accessibility make it a prime target for immunomodulation.
  • Immunomodulation aims to manipulate immune responses for therapeutic benefits.

Purpose of the Study:

  • To review advances in transdermal delivery for immune response modulation.
  • To discuss the biological basis and challenges of skin-based immunomodulation.
  • To highlight technological approaches for enhancing transdermal immunomodulatory therapeutics.

Main Methods:

  • Literature review of scientific advancements in transdermal immunomodulation.
  • Analysis of biological mechanisms underlying skin immunity.
  • Evaluation of technological strategies for drug delivery into the skin.

Main Results:

  • Summarizes progress in using transdermal delivery for vaccination and tolerization.
  • Details disease-specific applications in cancer, infections, and allergies.
  • Identifies key challenges and technological solutions in transdermal immunomodulation.

Conclusions:

  • Transdermal immunomodulation offers a promising route for treating various diseases.
  • Technological innovations are crucial for overcoming delivery challenges.
  • Future research should focus on practical considerations for clinical translation.