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Cardiac telocytes. From basic science to cardiac diseases. II. Acute myocardial infarction

Sorin Hostiuc1, Mihai Marinescu1, Mihnea Costescu1

  • 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
|April 1, 2018
PubMed

Insights

Current evidence does not confirm significant roles for telocytes in myocardial regeneration after myocardial infarction. Further research is needed to correctly characterize telocytes and differentiate them from similar cell types.

Area of Science:

  • Cardiovascular Biology
  • Cellular Regeneration
  • Stem Cell Research

Background:

  • Myocardial infarction (MI) is a leading cause of mortality worldwide.
  • Understanding the cellular mechanisms of cardiac repair is crucial for developing effective treatments.
  • Telocytes are a distinct cell population with potential regenerative properties.

Purpose of the Study:

  • To systematically review and evaluate the existing scientific evidence on the role of telocytes in myocardial infarction.
  • To assess the current understanding of telocyte involvement in cardiac regeneration post-MI.

Main Methods:

  • A comprehensive systematic literature review was conducted.
  • Searches were performed across major scientific databases: PubMed, Web of Science, and Scopus.
  • Six relevant articles investigating the link between myocardial infarction and telocytes were identified.

Main Results:

  • The reviewed studies did not provide conclusive evidence for a significant role of telocytes in myocardial regeneration after infarction.
  • Existing research has not definitively established the functional contribution of telocytes to cardiac repair processes.

Conclusions:

  • Current evidence is insufficient to confirm a significant role for telocytes in myocardial regeneration post-MI.
  • Future studies must focus on accurate telocyte characterization and differentiation from similar cell types, particularly endothelial progenitors.
  • Distinguishing telocytes from other cells with similar morphology and immunophenotypes is essential for advancing research in cardiac regeneration.
Abstract

Keywords:
Acute myocardial infarctionCardiac telocytesEndothelial progenitorsICLC

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