Related Experiment Video

Updated: Feb 12, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Prognostic value of global longitudinal strain in heart failure patients treated with cardiac resynchronization

Mand J H Khidir1, Rachid Abou1, Dilek Yilmaz1

  • 1Heart Lung Center, Leiden University Medical Center, Leiden, The Netherlands.

Heart Rhythm
|April 1, 2018
PubMed

Insights

Impaired left ventricular global longitudinal strain (GLS) predicts worse outcomes in heart failure patients receiving cardiac resynchronization therapy (CRT). Lower GLS indicates a higher risk of mortality and heart failure events post-CRT.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Myocardial fibrosis contributes to impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients.
  • LV GLS is a key indicator of cardiac function and fibrosis.

Purpose of the Study:

  • To assess the prognostic significance of LV GLS in HF patients undergoing cardiac resynchronization therapy (CRT).
  • To determine if baseline LV GLS predicts adverse outcomes after CRT.

Main Methods:

  • 829 HF patients treated with CRT had their LV GLS measured via 2D speckle tracking echocardiography before implantation.
  • Primary endpoint: all-cause mortality, heart transplantation, or LV assist device implantation.
  • Secondary endpoint: ventricular arrhythmias or appropriate defibrillator therapies.

Main Results:

  • Patients with the lowest LV GLS quartile had double the risk of the primary endpoint compared to those with the highest GLS.
  • Baseline LV GLS was independently associated with the combined primary endpoint (HR 1.075, P = .007) after multivariable adjustment.
  • LV GLS was not independently associated with the secondary endpoint (ventricular arrhythmias/defibrillator therapies).

Conclusions:

  • Baseline LV GLS is an independent predictor of adverse outcomes in HF patients treated with CRT.
  • LV GLS provides valuable prognostic information beyond traditional clinical and echocardiographic parameters.
Abstract

Keywords:
FibrosisHeart failureImplantable defibrillator deviceLeft ventricular mechanicsPrognosis

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