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Platelet monoamine oxidase activity in patients with Huntington's disease
T R Norman1, E Chiu, M A French
1Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Clinical and Experimental Pharmacology & Physiology
|June 1, 1987
Abstract:
1. Platelet monoamine oxidase (MAO) activity was investigated in 30 patients with Huntington's disease and compared with the activity in a control group. 2. Significantly elevated activity was found in the patients (P less than 0.05; t-test) when same sex contrasts were carried out to account for the well known influence of sex on MAO activity. 3. The mean MAO activity in male patients was 23.5 +/- 6.0 nmol/mg protein per h and female patients was 29.5 +/- 8.9 nmol/mg protein per h using tyramine as the substrate. 4. The possible influence of environmental factors on the results is discussed.