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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Venous Thromboembolism in Children with Sickle Cell Disease: A Retrospective Cohort Study

Gary M Woods1, Ruchika Sharma2, Susan Creary3

  • 1Division of Pediatric Hematology/Oncology, Children's Hospital of the King's Daughters, Norfolk, VA.

The Journal of Pediatrics
|April 2, 2018
PubMed

Insights

Nearly 3% of children with sickle cell disease (SCD) experienced venous thromboembolism (VTE). Central venous catheter (CVC) use was identified as an independent risk factor for VTE in this pediatric population.

Area of Science:

  • Hematology
  • Pediatric Thrombosis
  • Sickle Cell Disease Research

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder associated with an increased risk of venous thromboembolism (VTE).
  • Understanding VTE incidence and risk factors in pediatric SCD patients is crucial for effective prevention and management strategies.

Purpose of the Study:

  • To determine the cumulative incidence of VTE in children with SCD.
  • To identify clinical risk factors associated with VTE development in this patient group.

Main Methods:

  • Retrospective chart review of pediatric patients (0-21 years) with SCD at a single institution over a 6-year period.
  • Data collected included VTE diagnosis, demographics, SCD genotype, clinical complications, central venous catheter (CVC) placement, and thrombophilia testing.

Main Results:

  • The cumulative incidence of VTE was 2.9% (12/414) among children with SCD.
  • Central venous catheter (CVC) presence was the only independent risk factor for VTE on multivariable analysis (OR 33.8).
  • Other univariate risk factors included hemoglobin SS genotype, central nervous system vasculopathy, chronic transfusion therapy, and older age.

Conclusions:

  • Approximately 3% of children with SCD at this institution experienced VTE.
  • Central venous catheter (CVC) placement is a significant independent predictor of VTE in children with sickle cell disease.
Abstract

Keywords:
sickle cell diseasevenous thromboembolism

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