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Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

557
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
557
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

527
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
527
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

266
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
266
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

402
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
402

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Related Experiment Video

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Phage-Mediated Genetic Manipulation of the Lyme Disease Spirochete Borrelia burgdorferi
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Lyme Endocarditis.

Ana C Paim1, Larry M Baddour1, Bobbi S Pritt2

  • 1Division of Infectious Diseases, Mayo Clinic, Rochester, Minn.

The American Journal of Medicine
|April 2, 2018
PubMed
Summary

This study reports the first US case of Lyme endocarditis confirmed by molecular diagnostics. The rare condition involves Borrelia burgdorferi infection of heart valves, presenting diagnostic challenges.

Keywords:
16S rRNA PCRBorrelia burgdorferiCarditisEndocarditisLyme disease

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Area of Science:

  • Infectious Diseases
  • Cardiology
  • Molecular Diagnostics

Background:

  • Valvular involvement in Lyme carditis is a rare manifestation of Lyme disease.
  • Previous cases of Lyme endocarditis confirmed by molecular diagnostics have been reported from Europe.
  • This study details the first case in the United States confirmed by molecular diagnostics.

Observation:

  • A 68-year-old man presented with progressive dyspnea and severe mitral valve insufficiency.
  • Transesophageal echocardiogram revealed mitral valve perforation.
  • Resected valve tissue showed acute inflammation but no organisms on initial examination.

Findings:

  • Blood and valve tissue cultures were negative for bacterial growth.
  • 16S ribosomal RNA polymerase chain reaction and sequencing of valve tissue confirmed Borrelia burgdorferi.
  • This molecular confirmation is crucial for diagnosing Lyme endocarditis.

Implications:

  • Lyme endocarditis is challenging to diagnose due to its rarity and the need for specialized molecular testing.
  • The findings highlight the importance of considering Lyme endocarditis in patients with culture-negative endocarditis and tick exposure.
  • Molecular diagnostics are essential for confirming Borrelia burgdorferi in valvular tissue.