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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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The hematopoietic stem cell diet.

Adam C Wilkinson1,2, Satoshi Yamazaki3

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA, USA.

International Journal of Hematology
|April 2, 2018
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) rely on specific metabolic processes for their function and survival. Understanding HSC nutrition and metabolism offers new therapeutic avenues for blood disorders and transplantation.

Keywords:
HSCHematopoietic stem cellHematopoietic stem cell transplantationLeukemiaMetabolismNutrition

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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Metabolic Research

Background:

  • Hematopoietic stem cells (HSCs) are crucial for lifelong blood production and are used in bone marrow transplantation for treating hematological diseases.
  • The HSC microenvironment, or niche, comprises cellular, molecular, and metabolic factors influencing HSC function.
  • Metabolic pathways are increasingly recognized as critical regulators of HSC activity, with dysregulation linked to pathologies like leukemia.

Purpose of the Study:

  • To review recent advancements in understanding the metabolic requirements of HSCs.
  • To explore how nutrition impacts HSC function and activity.
  • To highlight potential metabolic strategies for enhancing HSC transplantation and leukemia therapies.

Main Methods:

  • Literature review of recent scientific progress in HSC metabolism and nutrition.
  • Analysis of current understanding of HSC "dietary" needs.
  • Synthesis of findings related to metabolic influences on HSC function.

Main Results:

  • Metabolic activity is intrinsically linked to HSC function.
  • Nutritional factors significantly influence HSC activity and behavior.
  • Dysregulation of metabolic pathways contributes to hematological diseases.

Conclusions:

  • Emerging research on HSC metabolism and nutrition provides novel insights.
  • Metabolic approaches show promise for improving HSC transplantation outcomes.
  • Targeting HSC metabolism may offer new strategies for leukemia treatment.