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Updated: Feb 12, 2026
12:18
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
23.7K
Effect of Intranasal Mupirocin Prophylaxis on Methicillin-Resistant Staphylococcus aureus Transmission and Invasive
Elizabeth H Ristagno1, Kristina A Bryant2, Lynette F Boland3
11Division of Pediatric Infectious Diseases,Mayo Clinic,Rochester,Minnesota.
Infection Control and Hospital Epidemiology
|April 3, 2018
Summary
Monthly intranasal mupirocin significantly reduced methicillin-resistant Staphylococcus aureus (MRSA) transmission and invasive infections in a neonatal intensive care unit. Mupirocin resistance was rare and did not cause adverse clinical outcomes.
Area of Science:
- Infectious Disease Epidemiology
- Antimicrobial Resistance
- Neonatal Intensive Care
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat in healthcare settings, particularly neonatal intensive care units (NICUs).
- Standard infection control measures may not be sufficient to eliminate MRSA transmission in high-risk populations.
Purpose of the Study:
- To evaluate the efficacy of monthly intranasal mupirocin in reducing MRSA transmission and invasive infections.
- To assess the emergence and clinical impact of mupirocin resistance during the intervention.
Main Methods:
- A large-scale intervention in a NICU utilizing monthly intranasal mupirocin application.
- Monitoring of MRSA transmission rates and invasive infection incidence.
- Surveillance for mupirocin resistance in Staphylococcus aureus isolates.
Main Results:
- A significant reduction in both MRSA transmission and invasive Staphylococcus aureus infections was observed.
- Mupirocin resistance emerged in Staphylococcus aureus over the study period.
- The rare instances of mupirocin resistance were not linked to adverse clinical outcomes.
Conclusions:
- Monthly intranasal mupirocin is an effective strategy for decreasing MRSA transmission and infections in NICUs.
- While mupirocin resistance can develop, it appears to be clinically insignificant in this context.
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