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Updated: Feb 12, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
[Transplantation strategy in type 1 diabetic patients]
Fanny Buron1, Lionel Badet2, Emmanuel Morelon1
1Service de néphrologie, transplantation et immunologie clinique, hôpital Édouard-Herriot, hospices civils de Lyon, place d'Arsonval, 69437 Lyon cedex 3, France.
Abstract:
Beta cell replacement by pancreas or Langerhans islets transplantation is the only way to restore glucose homeostasis in type 1 diabetic patients. The counterpart is the need for long-term immunosuppression. These transplantations are therefore mainly indicated for patients candidates for kidney transplantation and for patients with poor quality of life due to unstable diabetes with life-threatening hypoglycemic events. Both beta cell replacement techniques have different benefits and risks and should be adapted to each type 1 diabetic patient. The transplant strategy must be personalized according to parameters assessed in the pre-transplant period, validated by a multidisciplinary team and reassessed regularly until transplantation.
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