Related Experiment Video

Updated: Feb 12, 2026

Preparation of a Blood Culture Pellet for Rapid Bacterial Identification and Antibiotic Susceptibility Testing
11:25

Preparation of a Blood Culture Pellet for Rapid Bacterial Identification and Antibiotic Susceptibility Testing

Published on: October 15, 2014

36.6K

Antibiotic Susceptibility and Treatment Response in Bacterial Skin Infection

Ji Soo Lim1, Hyun-Sun Park1, Soyun Cho1

  • 1Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Annals of Dermatology
|April 3, 2018
PubMed
Abstract

Insights

Community-acquired bacterial skin infections are often caused by Staphylococcus aureus. High antibiotic resistance and non-systemic antibiotic use were linked to poorer treatment outcomes in young patients.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Bacterial skin infections, frequently caused by Staphylococcus aureus and Streptococci, arise from compromised skin barriers or as primary infections like impetigo.
  • Increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) poses a growing challenge.

Purpose of the Study:

  • To characterize community-acquired bacterial skin infections in young outpatients.
  • To analyze antibiotic susceptibility patterns of causative pathogens.
  • To identify factors influencing treatment response.

Main Methods:

  • Retrospective review of 197 outpatients under 30 years old (2010-2015).
  • Analysis of skin swab cultures and antibiotic susceptibility testing results.
  • Collection of clinical and microbiological data from medical records.

Main Results:

  • Staphylococcus aureus was the most common pathogen (52.6%), with high resistance to penicillin (90.9%) and oxacillin (36.3%).
  • 86.3% of patients achieved initial treatment response.
  • Multivariable analysis revealed that resistance to multiple antibiotics, high bacterial load, and non-systemic antibiotic use were associated with lower treatment response.
  • Methicillin resistance did not significantly impact treatment response.

Conclusions:

  • Staphylococcus aureus is the predominant pathogen in bacterial skin infections among young patients.
  • High-level antibiotic resistance and non-systemic antibiotic use correlate with reduced treatment efficacy.
  • First-generation cephalosporins are recommended as effective first-line empirical treatment for outpatient bacterial skin infections, irrespective of methicillin resistance status.
Keywords:
Antibiotic susceptibilityBacterial skin infectionInfectious skin diseasesMethicillin resistance

More Related Videos

Stress-induced Antibiotic Susceptibility Testing on a Chip12:41

Stress-induced Antibiotic Susceptibility Testing on a Chip

Published on: January 8, 2014

6.9K
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.4K

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
60.2K
Bacterial Transformation01:33

Bacterial Transformation

In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
60.2K
Magnetic Susceptibility and Permeability01:31

Magnetic Susceptibility and Permeability

In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.4K
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
84.1K
Susceptibility, Permittivity and Dielectric Constant01:26

Susceptibility, Permittivity and Dielectric Constant

When placed in an external electric field, a dielectric material gets polarized. The charge density in the dielectric material is given by the sum of the bound and free charge densities, while the total charge density can also be written in terms of the total electric field. The bound charge density can be measured in terms of polarization, leading to the relationship between electric displacement and polarization.
3.0K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.6K