Related Experiment Video
Updated: Feb 12, 2026
05:49
Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder
Published on: October 13, 2018
12.9K
Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review.
Kathryn Speer1, Dominic Upton2, Stuart Semple1,3
1Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Canberra, ACT, Australia.
Journal of Inflammation Research
|April 3, 2018
Summary
Post-traumatic stress disorder (PTSD) is linked to systemic inflammation, a potential driver of chronic disease. Reducing inflammation through interventions like exercise may benefit individuals with PTSD.
Area of Science:
- Psychiatry and Immunology
- Chronic Disease Epidemiology
Background:
- Post-traumatic stress disorder (PTSD) is associated with chronic disease.
- A systemic pro-inflammatory state is proposed to link PTSD and chronic disease.
Purpose of the Study:
- To systematically review evidence linking PTSD and systemic low-grade inflammation.
- To evaluate the role of inflammation in chronic disease development in PTSD.
Main Methods:
- Systematic literature review (January 2006-April 2017) using PubMed, MEDLINE, PsycINFO, SPORTDiscus.
- Included peer-reviewed human studies measuring systemic inflammation markers.
- Nine studies were selected for analysis.
Main Results:
- Systemic inflammatory biomarkers were generally elevated in individuals with PTSD.
- Evidence supports a link between PTSD and systemic low-grade inflammation.
- Inflammation may mediate the increased risk of chronic disease in PTSD.
Conclusions:
- PTSD is associated with a systemic low-grade inflammatory state.
- This inflammation may explain the heightened risk for chronic diseases in PTSD patients.
- Future research should explore anti-inflammatory interventions, such as exercise.
Related Concept Videos
01:27Post-traumatic Stress Disorder
590
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
590
01:38Inflammation
62.4K
Overview
62.4K
01:10Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
01:13Review and Preview
11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
01:19Graded Potential
7.1K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.1K
01:20Random and Systematic Errors
15.3K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.3K