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Updated: Feb 12, 2026

Orthotopic Left Lung Transplantation in Rats
Published on: July 3, 2025
A novel strategy for cardiopulmonary support during lung transplantation
Ramiro Fernandez1, Malcolm M DeCamp1, Ankit Bharat1
1Division of Thoracic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Abstract:
Contemporary modalities for cardiopulmonary support during lung transplantation include traditional cardiopulmonary bypass (CPB) and venoarterial extracorporeal membrane oxygenation (VA-ECMO). While highly effective, both are associated with morbidities such as arteriopathy and bleeding diathesis. In this report, we describe a novel approach for cardiopulmonary support during double lung transplantation in a patient with end-stage lung disease, pulmonary hypertension and moderate right ventricle (RV) dysfunction, using a percutaneous dual lumen cannula placed via the jugular vein which allowed us to achieve both RV bypass and membrane oxygenation. The cannula was left in place to provide ongoing RV support and the patient was successfully decannulated at bedside on post-operative day (POD) 2. Lack of arterial cannulation, percutaneous access, and bedside decannulation are benefits of this strategy, rendering this approach a useful addition to the armamentarium for CPB techniques in lung transplantation.
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