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Differences Between APOE Carriers and Non-APOE Carriers on Neurocognitive Tests: Jensen Effects?
Jan Te Nijenhuis1,2, Kyu Yeong Choi1,3, Yu Yong Choi1,3
11 National Research Center for Dementia, Chosun University, Gwangju, Republic of Korea.
Background:
Being a carrier of the apolipoprotein E (APOE) ε4 allele is a clear risk factor for development of Alzheimer's disease (AD). On some neurocognitive tests, there are smaller differences between carriers and noncarriers, while other tests show larger differences.
Aims:
We explore whether the size of the difference between carriers and noncarriers is a function of how well the tests measure general intelligence, so whether there are Jensen effects.
Methods:
We used the method of correlated vectors on 441 Korean older adults at risk for AD and 44 with AD.
Results:
Correlations between APOE carriership and test scores ranged from -.05 to .11 (normal), and -.23 to .54 (AD). The differences between carriers and noncarriers were Jensen effects: r = .31 and r = .54, respectively.
Conclusion:
A composite neurocognitive score may show a clearer contrast between APOE carriers and noncarriers than a large number of scores of single neurocognitive tests.
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