Related Experiment Video

Updated: Feb 12, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
09:57

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

2.4K

Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats

Chunhua Wang1,2, Songsheng Shi1,2, Quan Chen1

  • 11 Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China.

Integrative Cancer Therapies
|April 3, 2018
PubMed

Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. It remains unknown whether the GL-PS have any immunomodulatory and anticancer effects on brain glioma. This study was designed to identify and characterize the antitumor action and influence of immune system of GL-PS in glioma-bearing rats. Results showed that GL-PS increased the concentration of serum interleukin-2, tumor necrosis factor-α, and interferon-γ, and enhanced the cytotoxic activity of natural killer cells and T cells, promoting the functional maturation of dendritic cells, thus resulting in the inhibition of glioma growth and prolonged survival of rats. Therefore, GL-PS may be potentially useful as part of the treatment regimen to regulate host immune responses and increase the antitumor effects of immunotherapy for glioma.

Keywords:
Ganoderma lucidum polysaccharidesantitumorgliomaimmunomodulationtumor-bearing rat model

More Related Videos

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.5K
Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

991

Related Concept Videos

Biosynthesis of Polysaccharides01:26

Biosynthesis of Polysaccharides

Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
722
Cellulose and Pectic Polysaccharides01:15

Cellulose and Pectic Polysaccharides

 Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth.  Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
5.0K
Azimuths and Bearings01:19

Azimuths and Bearings

Azimuths and bearings are essential concepts in surveying, providing methods to express the direction of a line relative to a meridian. Azimuths refer to the clockwise angle measured from the north end of a reference meridian to the given line, ranging from zero to 360 degrees. This method gives a comprehensive directional reference within a full 360-degree circle, making it a straightforward way to communicate direction in various fields, including navigation, cartography, and...
687
Collar Bearings01:23

Collar Bearings

Collar bearings are essential in various machines designed to support axial loads on rotating shafts. Depending on the specific application and requirements, they can be found with single or multiple collars.
1.7K
Bearing Stress01:22

Bearing Stress

Bearing stress refers to the contact pressure between two separate bodies. To visualize this, imagine a bolt thrust through a plate. The bolt applies a force to the plate, which exerts an equal but opposite force back onto the bolt. This force isn't just a singular entity but a compilation of numerous smaller forces distributed across the contact surface between the bolt and the plate.
Due to the intricacy of these microforces, an average value, known as bearing stress, is often used by...
2.2K
Pivot Bearings01:23

Pivot Bearings

In mechanical systems, bearings are crucial in facilitating relative motion between two components while minimizing friction and wear. They help distribute various loads (radial, axial or a combination of both loads) across machinery parts, ensuring smooth and efficient operation.
A pivot bearing is a specialized type of bearing designed to support axial loads on a rotating shaft. The bearing surface, or the pivot, is positioned at the end of a shaft to support the axial thrust. The pivot may...
2.2K