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Updated: Feb 12, 2026

Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
Published on: January 8, 2016
Synergic highly effective photothermal-chemotherapy with platinum prodrug linked melanin-like nanoparticles
Chengwei Zhang1, Xiaozhi Zhao1, Hongqian Guo1
1a Department of Urology , Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University , Nanjing , P. R. China.
Abstract:
Cisplatin is widely used in cancer treatment, but the application is limited due to toxicities and its acquired resistance. In this study, we delivered cisplatin to prostate cancer cells by linking the platinum prodrug Pt(IV) to melanin-like nanoparticles (MeNPs), a promising photothermal therapeutic agent with excellent biocompatibility. As expected, the Pt(IV)-MeNPs exhibited brilliant synergic photothermal-chemotherapy upon near-infrared reflection exposure. Compared with free cisplatin, Pt(IV)-MeNPs displayed highly effective antitumour activity both in vitro and in vivo.
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