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Published on: June 27, 2025
T cell Large Granular Lymphocytic Leukemia with Pulmonary Hypertension
Sidra Khalid1, Hamed Daw2, Miriam Jacob3
1Internal Medicine, Fairview Hospital, Cleveland Clinic, Cleveland, USA.
T cell large granular lymphocytic leukemia, a rare blood cancer, may be linked to pulmonary hypertension. Treating the leukemia improved the patient's pulmonary hypertension, suggesting a shared cause.
Area of Science:
- Hematology
- Cardiology
- Oncology
Background:
- T cell large granular lymphocytic leukemia (TLGL) is a clonal proliferation of cytotoxic T lymphocytes.
- Pulmonary hypertension (PH) is a severe condition characterized by high blood pressure in the lung arteries.
Observation:
- A patient diagnosed with TLGL subsequently developed pulmonary hypertension.
- The patient received methotrexate for TLGL and selexipag and ambrisentan for PH.
Findings:
- Treatment of TLGL with methotrexate led to a significant improvement in the patient's pulmonary hypertension, from NYHA class IV to class I.
- This clinical course suggests a potential etiopathological link between TLGL and secondary pulmonary hypertension.
Implications:
- This case highlights a possible connection between T cell large granular lymphocytic leukemia and pulmonary hypertension.
- Further research may elucidate the mechanisms underlying this association and inform treatment strategies.
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