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Allergic Bronchopulmonary Mycosis Due to Schizophyllum commune Treated Effectively with Voriconazole
Takashi Ishiguro1, Naho Kagiyama1, Ayako Kojima1,2
1Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.
Abstract:
A 63-year-old woman presented to our hospital for cough, sputum, and abnormal shadows on chest X-ray. Schizophyllum commune was isolated from mucous plugs. Positive specific IgE and IgG against the fungi, elevated serum IgE, and mucous plugs with typical histologic findings of allergic bronchopulmonary mycosis (ABPM) led to the diagnosis of ABPM due to S. commune. We initially administered itraconazole unsuccessfully. Changing the antifungal agent to voriconazole resulted in improvement of the symptoms and chest imaging findings. Her ABPM has not relapsed for two years since the cessation of voriconazole, which was administered for one year.
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