Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

19.0K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
19.0K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

4.0K
4.0K
Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
Integration by Parts: Indefinite Integrals01:26

Integration by Parts: Indefinite Integrals

230
Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
230
Integration by Parts: Definite Integrals01:23

Integration by Parts: Definite Integrals

92
Definite integrals involving the product of two functions over a fixed interval can be evaluated using integration by parts. This method rewrites the integral as the difference of a product evaluated at the endpoints and a remaining definite integral that is often simpler to compute.A representative example is the definite integral of the inverse tangent function. Since there is no direct integration formula for arctan ⁡x, the integrand is rewritten as a product of arctan⁡ x and the...
92
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

3.5K
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wave changes in intraoperative transcranial motor-evoked potentials during posterior decompression and dekyphotic corrective fusion with instrumentation for thoracic ossification of the posterior longitudinal ligament.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2019
Same author

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients.

Translational psychiatry·2019
Same author

Re-challenge chemotherapy in patients with sensitive relapse small-cell lung cancer and interstitial lung disease.

Journal of thoracic disease·2019
Same author

Optimal stimulation intensity for Br(E)-MsEP waveform derivation at baseline in pediatric spinal surgery.

Clinical neurology and neurosurgery·2019
Same author

Impact of comorbidity rates of lumbar spondylosis, knee osteoarthritis, and osteoporosis on physical QOL and risk factors for poor physical QOL in middle-aged and elderly people.

Modern rheumatology·2019
Same author

A comparative study of two reconstruction procedures for osteoporotic vertebral fracture with lumbar spinal stenosis: Posterior lumbar interbody fusion versus posterior and anterior and combined surgery.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association·2019
Same journal

[Effect of Application Device Design on Scalp Delivery of Topical Minoxidil Formulations].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[Survey of Pharmaceutical Interventions in Outpatient Cancer Chemotherapy].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

Effects of Fluctuating Triglyceride Levels on Initial and Steady-state Serum Amiodarone Concentrations in Japanese Patients: A Retrospective Study.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[Dynamic Oligomerization Processes and Functional Characterization of Bacterial ClpP Protease].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[Structural Analysis Using Cryo-electron Microscopy for Protein-based Drug Design].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[Expansion of Targeted Protein Degradation for Targeting Aggregate-prone Proteins and Mitochondrial Proteins].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

33.5K

[Recent Progress in Promoting Research Integrity].

Satoshi Tanaka1

  • 1Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|April 3, 2018
PubMed
Summary
This summary is machine-generated.

Research integrity is vital in medicine and life sciences, with misconduct impacting reproducibility. Understanding research misconduct helps foster a sound research environment for all scientists.

Keywords:
research ethicsresearch integrityresearch misconductresearch practice

More Related Videos

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.1K
Plant Promoter Analysis: Identification and Characterization of Root Nodule Specific Promoter in the Common Bean
10:58

Plant Promoter Analysis: Identification and Characterization of Root Nodule Specific Promoter in the Common Bean

Published on: December 23, 2017

13.1K

Related Experiment Videos

Last Updated: Feb 12, 2026

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

33.5K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.1K
Plant Promoter Analysis: Identification and Characterization of Root Nodule Specific Promoter in the Common Bean
10:58

Plant Promoter Analysis: Identification and Characterization of Root Nodule Specific Promoter in the Common Bean

Published on: December 23, 2017

13.1K

Area of Science:

  • Medicine and Life Sciences
  • Pharmaceutical Sciences

Background:

  • Increasing cases of research misconduct and whistle-blowing raise public concern about research integrity.
  • Poor reproducibility in life science research, particularly in Europe and the United States, is linked to research misconduct.
  • Research integrity is critical in pharmaceutical sciences due to their role in medical and life sciences.

Purpose of the Study:

  • To address the under-investigation of research misconduct in Japan.
  • To promote in-depth discussions on research integrity by understanding misconduct.
  • To introduce contemporary practices for creating a sound research environment and discuss individual researcher roles.

Main Methods:

  • Review of contemporary activities in universities, pharmaceutical companies, and government agencies.
  • Analysis of the association between research misconduct and normal research activities.
  • Discussion of strategies for individual researchers to promote research integrity.

Main Results:

  • Research misconduct is closely associated with normal research activities, not just personality traits.
  • Various institutions are implementing activities to foster a sound research environment.
  • Individual researchers can actively promote research integrity.

Conclusions:

  • A comprehensive understanding of research misconduct is essential for maintaining research integrity.
  • Promoting research integrity requires a multi-faceted approach involving institutions and individual researchers.
  • Sound research environments are crucial for reliable advancements in medicine and life sciences.