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Updated: Feb 12, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Metabolism of Antifungal Thiochroman-4-ones by Trichoderma viride and Botrytis cinerea
Cristina Pinedo-Rivilla1, Isidro G Collado1, Josefina Aleu1
1Departamento de Química Orgánica, Facultad de Ciencias , Universidad de Cádiz , Campus Río S. Pedro, 11510 Puerto Real, Cádiz, Spain.
Abstract:
Biotransformation of 6-methylthiochroman-4-one (1) and 6-chlorothiochroman-4-one (2) was performed using Trichoderma viride in order to obtain new derivatives with antifungal properties against the phytopathogen Botrytis cinerea. Two thiochromanone derivatives are described for the first time. Antifungal activity of these compounds was tested against two different strains of Botrytis cinerea; 1 and 2 gave 100% inhibition of Bc2100 at 100-250 μg/mL, and 3 gave a maximal inhibition of 96% of BcUCA992 at 200 μg/mL. The detoxification mechanism of 1 and 2 by B. cinerea was also investigated.
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