Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Down's syndrome: intellectual and behavioural functioning during adulthood.

M E Fenner1, K E Hewitt, D M Torpy

  • 1Department of Clinical Psychology, Stoke Park Hospital, Bristol, England.

Journal of Mental Deficiency Research
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury.

Brain research·2001
Same author

Selective coupling of mu-calpain activation with the NMDA receptor is independent of translocation and autolysis in primary cortical neurons.

Journal of neuroscience research·1998
Same author

An investigation of the possible interaction of clomethiazole with glutamate and ion channel sites as an explanation of its neuroprotective activity.

Pharmacology & toxicology·1998
Same author

Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats.

Neuropharmacology·1994
Same author

Behavioural treatment for sleep disturbance.

Health visitor·1993
Same author

Pre-school. health visitor based services for pre-school children with behaviour problems.

Health visitor·1990
Same journal

Increased activity of pyridoxal kinase in tongue in Down's syndrome.

Journal of mental deficiency research·1991
Same journal

Effect of thyroid stimulating hormone on adaptive behaviour in Down's syndrome.

Journal of mental deficiency research·1991
Same journal

Behavioural observations in children with Down's syndrome.

Journal of mental deficiency research·1991
Same journal

Balanced chromosomal translocations and mental illness.

Journal of mental deficiency research·1991
Same journal

Mental retardation and WAIS-R difference scores.

Journal of mental deficiency research·1991
Same journal

The psychometric properties of the Behaviour Assessment Record (the BAR schedule).

Journal of mental deficiency research·1991
See all related articles

Intellectual deterioration occurred in less than a third of adults with Down's syndrome over 35 years. This challenges previous assumptions linking cognitive decline in older Down's syndrome patients directly to Alzheimer's disease.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Previous studies suggested cognitive decline in Down's syndrome over 35 years indicates Alzheimer's disease.
  • This was often correlated with post-mortem findings of Alzheimer's neuropathology.

Purpose of the Study:

  • To investigate the prevalence of intellectual deterioration in adults with Down's syndrome over 35 years.
  • To examine the relationship between age, self-care skills, and behavioral disturbances in this population.

Main Methods:

  • Cross-sectional study of Down's syndrome patients aged 19-49 years.
  • Assessed intellectual functioning, self-care skills, and behavioral disturbances.

Main Results:

  • Intellectual deterioration was present in less than one-third of Down's syndrome patients over 35 years.

Related Experiment Videos

  • No significant correlation found between chronological age and self-care skills or disturbed behavior.

    • Conclusions:

    • The findings question the universal link between aging over 35 in Down's syndrome and Alzheimer's disease-like cognitive decline.
    • Highlights the need for revised interpretations of neuropathological data and improved methodologies for future research.