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Related Concept Videos

Storage01:23

Storage

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A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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ATP Energy Storage and Release01:31

ATP Energy Storage and Release

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ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
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Sugars as Energy Storage Molecules

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Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
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Related Experiment Video

Updated: Feb 12, 2026

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
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Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin.

Florian Bourdeaux1, Christopher A Hammer2, Stephan Vogt3

  • 1Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence for Macromolecular Complexes , Goethe University Frankfurt , Max-von-Laue-Str. 15 , D-60438 Frankfurt am Main , Germany.

ACS Infectious Diseases
|April 3, 2018
PubMed
Summary

This study investigates Mycobacterium tuberculosis dodecin, revealing its pH-dependent flavin binding. This protein may be crucial for flavin homeostasis in M. tuberculosis, suggesting its potential as a drug target.

Keywords:
antibioticsflavoenzymesflavoproteinshomeostasispH controlstorage proteintuberculosis

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Area of Science:

  • Biochemistry
  • Microbiology
  • Structural Biology

Background:

  • Dodecins are small flavin-binding proteins found in archaea and bacteria.
  • Bacterial dodecins are prevalent in various pathogens, including Mycobacterium tuberculosis.
  • These proteins bind flavin dimers with their isoalloxazine rings shielded.

Purpose of the Study:

  • To elucidate the function of dodecins from Mycobacterium tuberculosis.
  • To characterize the thermodynamic and kinetic properties of flavin binding.
  • To gain mechanistic insights into dodecin function.

Main Methods:

  • Spectroscopic methods
  • Electrochemical methods
  • Thermodynamic and kinetic analyses

Main Results:

  • Detailed characterization of flavin binding properties.
  • Identification of significant pH dependence in flavin binding affinity and specificity.
  • Mechanistic insights into Mycobacterium tuberculosis dodecin function.

Conclusions:

  • Mycobacterium tuberculosis dodecin functions as a flavin storage and sequestering protein.
  • The protein's pH-dependent binding is critical for flavin homeostasis in M. tuberculosis.
  • Mycobacterium tuberculosis dodecin presents a potential drug target.