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Understanding the role of non-coding RNA (ncRNA) in stent restenosis

Shaoyan Liu1, Yanyan Yang2, Shaoyan Jiang3

  • 1Department of Cardiology, The Affiliated Hospital of Qingdao University, 266000, People's Republic of China.

Atherosclerosis
|April 3, 2018
PubMed

Insights

Coronary heart disease treatments like stents can cause complications. Non-coding RNAs (ncRNAs) show promise in regulating vascular responses and may offer new targets to prevent stent restenosis and thrombosis.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomedical Engineering

Background:

  • Coronary heart disease (CHD) is a leading cause of mortality.
  • Percutaneous coronary intervention with stent implantation is standard treatment for obstructive coronary artery disease.
  • Stents, as foreign bodies, can trigger vascular smooth muscle cell proliferation, immune responses, and neointima formation, leading to post-stent restenosis (ISR) and late thrombosis.

Purpose of the Study:

  • To review the regulatory roles of non-coding RNAs (ncRNAs) in cardiovascular disease.
  • To explore the potential of ncRNAs as therapeutic targets for preventing adverse vascular events after stent implantation.

Main Methods:

  • Literature review of studies on ncRNAs and cardiovascular disease.
  • Analysis of ncRNA regulatory mechanisms in vascular cells and inflammatory processes.
  • Synthesis of current knowledge on ncRNAs in the context of coronary stenting.

Main Results:

  • Non-coding RNAs (ncRNAs) are key regulators of endothelial and vascular smooth muscle cell function.
  • ncRNAs play significant roles in modulating inflammatory reactions relevant to cardiovascular pathology.
  • Specific ncRNAs have been implicated in the processes leading to ISR and thrombosis.

Conclusions:

  • ncRNAs represent a novel class of molecules with significant potential in cardiovascular disease regulation.
  • Targeting ncRNAs may offer a promising therapeutic strategy to prevent stent-related complications like ISR and thrombosis.
  • Further research into ncRNA mechanisms could lead to improved outcomes for patients undergoing coronary stenting.

Keywords:
Coronary artery diseaseImmune responseInflammationLong non-coding RNANon-coding RNARestonosismicroRNA

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