Related Experiment Video
Updated: Feb 12, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Long-term effects on cardiovascular risk of a structured multidisciplinary lifestyle program in clinical practice
Matthias Lidin1,2, Mai-Lis Hellénius3,4, Monica Rydell-Karlsson5,6
1Karolinska Institutet, Department of Medicine, Stockholm, Sweden. matthias.lidin@ki.se.
Insights
A lifestyle program significantly improved cardiovascular risk factors like obesity and hypertension over one year. This multidisciplinary approach reduced overall cardiovascular risk in participants with increased risk.
Area of Science:
- Cardiology
- Preventive Medicine
- Public Health
Background:
- Cardiovascular disease (CVD) remains a primary cause of global premature mortality.
- Key etiological factors include abdominal obesity, hypertension, and dyslipidemia.
- Individuals with elevated cardiovascular risk require effective interventions.
Purpose of the Study:
- To evaluate the impact of a multidisciplinary lifestyle program on cardiovascular risk factors.
- To assess changes in overall cardiovascular risk after 6 months and 1 year.
- To determine the program's effectiveness in a clinical setting for high-risk individuals.
Main Methods:
- A prospective study involving 100 individuals with increased cardiovascular risk.
- Intervention included individual consultations, health check-ups, and group educational sessions over 1 year.
- Cardiovascular risk was quantified using the Framingham cardiovascular risk prediction model.
Main Results:
- Significant reductions observed in waist circumference, blood pressure, and total cholesterol after 1 year.
- Overall cardiovascular risk decreased by 15% based on the Framingham 10-year risk prediction model.
- Benefits were consistent across genders and among participants with or without prior cardiovascular disease.
Conclusions:
- A structured, year-long lifestyle program effectively improves multiple cardiovascular risk factors.
- The intervention leads to a significant reduction in overall cardiovascular risk.
- This approach demonstrates clinical utility in managing individuals at high cardiovascular risk.
Background:
Cardiovascular disease is still the leading cause of premature death world-wide with factors like abdominal obesity, hypertension and dyslipidemia being central risk factors in the etiology. The aim of the present study was to investigate the effects on cardiovascular risk factors and cardiovascular risk after 6 months and 1 year, in individuals with increased cardiovascular risk enrolled in a lifestyle multidisciplinary program in a clinical setting.
Method:
Individuals with increased cardiovascular risk were referred from primary health care and hospitals to a program at an outpatient clinic at a department of cardiology. The program consisted of three individual visits including a health check-up with a physical examination and blood sampling, and a person-centered dialogue for support in behavioural change of unhealthy lifestyle habits (at baseline, 6 months and 1 year). Furthermore, five educational group sessions were given at baseline. Cardiovascular risk was assessed according to Framingham cardiovascular risk predicting model.
Results:
One hundred individuals (mean age 59 years, 64% women) enrolled between 2008 and 2014 were included in the study. Waist circumference, systolic and diastolic blood pressure and total cholesterol decreased significantly over 1 year. In parallel, cardiovascular risk according to the cardiovascular risk profile based on Framingham 10-year risk prediction model, decreased with 15%. The risk reduction was seen in both men and women, and in participants with or without previous cardiovascular disease.
Conclusion:
Participating in a structured lifestyle program over a year was associated with significant improvement in multiple cardiovascular risk factors and decreased overall cardiovascular risk.
Trial Registration:
The study is registered at www.clinicaltrials.gov (ClinicalTrial.gov ID: NCT02744157 ).
More Related Videos
07:10At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques
Published on: February 11, 2020
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Related Concept Videos
Introduction to Stress and Lifestyle
Lifestyle Factors and Health
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Relative Risk
Long-term Depression
Overview of the Cardiovascular System
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
Structure of Lipids