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Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate

H J de Voogt1, B R Rao, A A Geldof

  • 1Department of Urology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.

The Prostate
|January 1, 1987
PubMed

Insights

Androgen blockade in healthy males undergoing gender reassignment did not alter prostate volume. However, histological analysis revealed glandular atrophy and stromal tissue increase, suggesting subtle prostate tissue changes despite unchanged size.

Area of Science:

  • Endocrinology
  • Urology
  • Reproductive Medicine

Background:

  • Androgen blockade is a key component of feminizing hormone therapy.
  • The effects of long-term androgen blockade on the normal human prostate are not fully understood.

Purpose of the Study:

  • To investigate the impact of androgen blockade on prostate volume and histology in healthy males undergoing gender reassignment.

Main Methods:

  • 16 healthy male volunteers (ages 19-27) received anti-androgen treatment (Anandron, followed by cyproterone-acetate and ethinyl estradiol).
  • Prostate volume was measured using ultrasound before and after treatment.
  • Prostate histology was examined after 18 months of treatment.

Main Results:

  • Prostate volume remained unchanged after 8 weeks of Anandron and 18 months of cyproterone-acetate/ethinyl estradiol treatment.
  • Histological examination revealed significant glandular atrophy and an increase in stromal tissue.

Conclusions:

  • Androgen blockade does not significantly reduce prostate volume in healthy young males.
  • Despite unchanged volume, androgen blockade induces histological alterations in the prostate, including glandular atrophy and stromal hyperplasia.

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