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Updated: Feb 12, 2026

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
Airway disease phenotypes in animal models of cystic fibrosis
Alexandra McCarron1,2,3, Martin Donnelley4,5,6, David Parsons4,5,6
1Adelaide Medical School, Discipline of Paediatrics, University of Adelaide, Adelaide, SA, Australia. alexandra.mccarron@adelaide.edu.au.
Abstract:
In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered investigations of airway disease pathogenesis, as well as the development and testing of potential therapeutics. However, recently generated CF animal models including rat, ferret and pig models demonstrate a range of well characterised lung disease phenotypes with varying degrees of severity. This review discusses the airway phenotypes of currently available CF animal models and presents potential applications of each model in airway-related CF research.
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