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Statin Intolerance: Some Practical Hints.

Maciej Banach1, Dimitri P Mikhailidis2

  • 1Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz (MUL), 113 Zeromskiego Street, Lodz 90-549, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), 281/289 Rzgowska Street, Lodz 93-338, Poland; Cardiovascular Research Centre, University of Zielona Gora, 28 Zyty Street, Zielona Gora 65-046, Poland.

Cardiology Clinics
|April 4, 2018
PubMed
Summary
This summary is machine-generated.

Statin intolerance affects over 90% of patients, but a five-step approach can help manage cardiovascular risk. New therapies and nutraceuticals offer alternative lipid-lowering options when statins are not tolerated.

Keywords:
Adverse effectsCardiovascular diseaseStatin-associated muscle symptomsStatinsTherapy

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Area of Science:

  • Cardiology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Statin intolerance is a significant barrier to cardiovascular risk reduction.
  • Managing patients with statin intolerance requires effective therapeutic strategies.

Purpose of the Study:

  • To outline an approach for managing statin intolerance.
  • To explore alternative and adjunctive therapies for lipid management.

Main Methods:

  • Review of current clinical approaches for statin intolerance.
  • Evaluation of novel lipid-lowering agents and nutraceuticals.

Main Results:

  • A five-step approach can enable statin therapy in over 90% of intolerant patients.
  • Proprotein convertase subtilisin-kexin type 9 inhibitors and bempedoic acid show promise.
  • Nutraceuticals may supplement lipid-lowering therapy when goals are unmet.

Conclusions:

  • Effective management of statin intolerance is achievable.
  • A multi-faceted therapeutic strategy including novel agents and nutraceuticals can optimize cardiovascular risk reduction.