Related Experiment Video
Updated: Feb 12, 2026
13:04
A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
24.7K
Evolutionary Origins of Enteric Hepatitis Viruses
Anna-Lena Sander1,2, Victor Max Corman1,2, Alexander N Lukashev3,4
1Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin 10117, Germany.
Cold Spring Harbor Perspectives in Medicine
|April 4, 2018
Summary
Hepatitis A (HAV) and E (HEV) viruses
Area of Science:
- Virology
- Evolutionary Biology
- Hepatology
Background:
- Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are major causes of acute viral hepatitis.
- The evolutionary origins of HAV and HEV remain largely unknown despite their discovery decades ago.
Purpose of the Study:
- To investigate the evolutionary history and origins of primate and nonprimate hepatoviruses and hepeviruses.
- To identify conserved and divergent genomic features and trace interspecies transmission events.
Main Methods:
- Phylogenomic analyses of primate and nonprimate hepatoviruses and hepeviruses.
- Phylogenetic comparisons and recombination analyses to corroborate interspecies transmissions.
Main Results:
- Detailed phylogenomic analyses reveal conserved and divergent genomic properties among hepatoviruses and hepeviruses.
- Evidence suggests non-recent origins for human HAV and HEV precursors, likely transmitted by non-primate mammals.
- Current zoonotic HEV infections are detailed.
Conclusions:
- Novel nonprimate hepatoviruses and hepeviruses provide new avenues for research.
- Future research should focus on host range and the unique biological properties of HAV and HEV.
- Understanding viral evolution aids in controlling hepatitis transmission.
Related Concept Videos
02:35What is Evolutionary History?
43.7K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
43.7K
01:20Evolutionary Psychology
1.0K
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
1.0K
00:50What are Viruses?
128.4K
Overview
128.4K
01:23Criticisms of the Evolutionary Perspective
380
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
Evolutionary psychology provides one explanation for these findings, suggesting...
380
02:54Evolutionary Relationships through Genome Comparisons
7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
01:18Drug Delivery: Enteral Route
1.9K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.9K