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Updated: Feb 12, 2026

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
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One-Year Clinical Outcomes of Forty-Eight Millimeter Everolimus-Eluting Stent Implanted in Very Long Lesions: A

Gioel Gabrio Secco1, Matteo Tebaldi, Rosario Parisi

  • 1Interventional Cardiology, "Santi Antonio e Biagio e Cesare Arrigo" Hospital, Via Venezia 16, 15121 Alessandria, Italy. gioel.gabrio.secco@gmail.com.

The Journal of Invasive Cardiology
|April 4, 2018
PubMed

Insights

A 48 mm everolimus-eluting stent (EES) provides a safe and effective treatment for long coronary lesions. This study found no significant difference in outcomes compared to overlapping drug-eluting stents.

Area of Science:

  • Interventional Cardiology
  • Cardiovascular Research
  • Medical Device Technology

Background:

  • Long coronary lesions present treatment challenges with higher restenosis rates.
  • Overlapping stent struts may induce inflammatory reactions.
  • Evaluating novel stent solutions for complex coronary anatomies is crucial.

Purpose of the Study:

  • To assess the safety, feasibility, and cost-effectiveness of a 48 mm everolimus-eluting stent (EES).
  • To treat patients with very long coronary lesions.
  • To compare EES outcomes against conventional multi-stent strategies.

Main Methods:

  • Prospective data collection of 218 patients treated with 48 mm EES.
  • Propensity score matching to a control group of 218 patients receiving multiple second-generation drug-eluting stents.
  • Primary endpoint: device-oriented composite endpoint (DOCE) including cardiac death, target-vessel myocardial infarction, and target-lesion revascularization.

Main Results:

  • No significant difference in DOCE incidence between the 48 mm EES group (7%) and the control group (10.5%; P=.10).
  • Overall, 9% of patients reached the primary endpoint.
  • Myocardial infarction presentation and increased stent number were independent predictors of DOCE.

Conclusions:

  • The 48 mm EES is a safe and effective option for treating very long coronary lesions.
  • This approach simplifies treatment and potentially reduces complications associated with multiple overlapping stents.
Abstract

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