Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma

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Updated: Feb 12, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

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Yusuke Minami1, Seiichi Matsumoto1, Keisuke Ae1

  • 1Department of Orthopedic Surgery, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Case Reports in Orthopedics
|April 4, 2018
PubMed

Insights

Pelvic Ewing sarcoma with inferior vena cava (IVC) tumor thrombus is challenging. This case shows successful treatment with chemotherapy and irradiation, leading to long-term remission.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Surgical Oncology

Background:

  • Pelvic Ewing sarcoma presents a poor prognosis.
  • Thromboembolic events are common in pediatric cancer patients, including sarcomas.
  • Inferior vena cava (IVC) tumor thrombus complicates management.

Observation:

  • A pediatric patient with left iliac bone Ewing sarcoma had an IVC tumor thrombus.
  • The tumor extended into the sacral bone, complicating surgical resection.
  • MRI and CT scans confirmed tumor extent and IVC involvement.

Findings:

  • Combined chemotherapy (VCR, Act-D, IFM, ADR) and irradiation (31.2 Gy) achieved complete tumor response.
  • The IVC tumor thrombus completely resolved.
  • A lung metastasis 4 years post-treatment was resected, with no recurrence at 14 years.

Implications:

  • This case highlights the efficacy of multimodal therapy for pelvic Ewing sarcoma with IVC tumor thrombus.
  • Successful management can lead to long-term survival.
  • It underscores the importance of considering surgical and oncological interventions in complex cases.

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