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Updated: May 3, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis.

Mark Lebwohl1

  • 1Icahn School of Medicine at Mount Sinai, New York, New York (M.L.).

Annals of Internal Medicine
|April 4, 2018
PubMed
Summary
This summary is machine-generated.

Psoriasis is an inherited immune disorder affecting skin and joints, with systemic links to heart, metabolic, and brain conditions. Effective treatments range from topical therapies to advanced biologics.

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Area of Science:

  • Immunodermatology
  • Systemic Autoimmune Diseases

Background:

  • Psoriasis is an inherited immune system disorder.
  • It commonly manifests in the skin and joints.
  • Psoriasis is linked to cardiovascular, metabolic, and neuropsychiatric conditions.

Purpose of the Study:

  • To review the systemic associations of psoriasis.
  • To outline current and emerging treatment options for psoriasis and psoriatic arthritis.

Main Methods:

  • Literature review of psoriasis and its systemic effects.
  • Analysis of current therapeutic strategies, including topical, oral, phototherapy, and biologic agents.

Main Results:

  • Psoriasis involves more than skin and joints, impacting multiple organ systems.
  • Biologic therapies have significantly advanced psoriasis and psoriatic arthritis treatment.
  • Various treatment modalities exist, tailored to disease severity.

Conclusions:

  • Primary care physicians must recognize psoriasis's systemic nature.
  • Awareness of systemic associations and available treatments is crucial for comprehensive patient care.
  • Integrated management addressing both cutaneous and systemic aspects is recommended.