Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increasing Function01:18

Increasing Function

402
An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...
402
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
Increased Body Temperature01:25

Increased Body Temperature

7.5K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.5K
Increased pulse rate01:17

Increased pulse rate

1.2K
Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
1.2K
What is Gene Expression?01:42

What is Gene Expression?

197.1K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.1K
What is Gene Expression?01:36

What is Gene Expression?

11.6K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of WeChat Public Account Intervention Based on the Information-Motivation-Behavioral Skills Model Among College Students With Internet Addiction: Randomized Controlled Trial.

Journal of medical Internet research·2026
Same author

Photo-responsive Ce-hemin nanozyme-based portable colorimetric sensor for tetracyclines assay.

Mikrochimica acta·2026
Same author

Analysis of SOX2 and SOX17 expression in cervical HPV-associated adenocarcinoma in situ: Correlation with histologic variants.

Annals of diagnostic pathology·2026
Same author

Case Report: Ultra-early tangential excision combined with negative pressure wound therapy as a novel surgical detoxification strategy for severe hydrofluoric acid burns complicated by intractable hypocalcemia.

Frontiers in toxicology·2026
Same author

Surufatinib plus toripalimab for patients with advanced solid tumors and disease progression after prior immunotherapy: an open-label multi-cohort phase 2 trial.

Cancer immunology, immunotherapy : CII·2026
Same author

Multi-target positioning and motion tracking enabled by a compound meta-eye system.

Microsystems & nanoengineering·2026

Related Experiment Video

Updated: Feb 12, 2026

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

1.5K

Increased ZNF84 expression in cervical cancer.

Peng Li1, Hongsheng Guo1, Guangji Zhou1

  • 1Department of Histology and Embryology of Basic Medical Department, Guangdong Medical University, 1st, Xincheng Road of Songshan Lake, Dongguan, 523808, Guangdong, China.

Archives of Gynecology and Obstetrics
|April 4, 2018
PubMed
Summary

The ZNF84 gene is highly expressed in cervical cancer tissues and linked to tumor size. Inhibiting ZNF84 reduces cancer cell growth, potentially through the Akt signaling pathway.

Keywords:
AktCell proliferationCervical cancerZNF84

More Related Videos

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
07:30

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

Published on: December 2, 2022

7.4K
High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
10:02

High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes

Published on: July 25, 2015

19.7K

Related Experiment Videos

Last Updated: Feb 12, 2026

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

1.5K
Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
07:30

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model

Published on: December 2, 2022

7.4K
High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
10:02

High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes

Published on: July 25, 2015

19.7K

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Expression Analysis

Background:

  • The role of ZNF84 in cervical cancer (CC) is largely unknown.
  • Understanding ZNF84's function is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate ZNF84 gene expression in cervical cancer.
  • To determine the impact of ZNF84 on cervical cancer progression and cell proliferation.

Main Methods:

  • Immunohistochemistry was used to detect ZNF84 and Akt protein levels in CC tissues.
  • Cell proliferation was assessed using CCK-8 kits.
  • Western blotting and qPCR were employed to analyze Akt protein and mRNA expression.

Main Results:

  • ZNF84 protein expression was significantly higher in CC tissues compared to normal tissues.
  • ZNF84 expression correlated with tumor size and TNM staging in squamous cell carcinoma.
  • Inhibition of ZNF84 suppressed cancer cell proliferation and down-regulated Akt signaling.

Conclusions:

  • ZNF84 is upregulated in cervical cancer and associated with tumor size.
  • ZNF84 promotes cervical cancer cell proliferation, likely involving the Akt signaling pathway.