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Fluoride varnish versus glutaraldehyde for hypersensitive teeth: a randomized controlled trial, meta-analysis and
Gowri Sivaramakrishnan1, Kannan Sridharan2
1Department of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Brown Street, Suva, Fiji. gowri.sivaramakrishnan@gmail.com.
Clinical Oral Investigations
|April 4, 2018
Summary
Gluma significantly reduces tooth hypersensitivity at 7 days compared to Duraphat, though long-term effects require further study. Both agents improve quality of life for patients with sensitive teeth.
Area of Science:
- Dentistry
- Dental Materials Science
Background:
- Gluma and Duraphat are common in-office treatments for hypersensitive teeth.
- Evidence comparing their efficacy is limited.
Purpose of the Study:
- To compare the efficacy of Gluma and Duraphat in treating hypersensitive teeth.
- To evaluate their impact on oral health-related quality of life.
Main Methods:
- A randomized controlled trial involving 38 participants.
- Meta-analysis of four studies, including the present trial.
- Trial sequential analysis using the O'Brien-Fleming boundary approach.
Main Results:
- Both Gluma and Duraphat significantly reduced hypersensitivity and visual analog scale (VAS) scores at 5 minutes and 7 days.
- No significant difference in efficacy was observed between the two agents in the randomized trial.
- Gluma demonstrated a significant reduction in VAS scores at 7 days in the meta-analysis.
- Oral health-related quality of life (OHIP) scores improved significantly for both treatment groups.
Conclusions:
- Gluma shows a significant reduction in hypersensitivity at 7 days compared to Duraphat.
- Further research is needed to assess long-term effects, adverse events, and cost-effectiveness.
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