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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Current and Emerging Therapeutic Targets for Metastatic Renal Cell Carcinoma

Kevin Zarrabi1, Shenhong Wu2,3

  • 1Department of Medicine, Stony Brook University Hospital, Stony Brook, NY, USA.

Current Oncology Reports
|April 4, 2018
PubMed
Abstract

Insights

Recent advances in renal cell carcinoma treatment include targeted therapies and immunotherapy, shifting from older cytokine-based methods. These novel approaches offer improved survival but face challenges with treatment resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Advanced renal cell carcinoma treatment has undergone significant evolution.
  • Traditional therapies relied on cytokine-based agents.
  • Improved understanding of tumorigenesis and molecular mechanisms drives new therapeutic strategies.

Purpose of the Study:

  • To review current and emerging molecularly targeted therapies for advanced renal cell carcinoma.
  • To provide insights into treatment strategies for metastatic renal cell carcinoma.

Main Methods:

  • Review of recent literature on targeted therapies and immunotherapies for renal cell carcinoma.
  • Analysis of treatment paradigms shifting towards molecular targets.

Main Results:

  • Paradigm shift from cytokine-based agents to targeted therapies (tyrosine kinase inhibitors, mTOR inhibitors, monoclonal antibodies) and immunotherapy.
  • Immunotherapy targeting T-lymphocyte checkpoints enhances overall survival.
  • Durable responses are increasingly observed with novel agents and combinations, despite ongoing challenges with treatment resistance.

Conclusions:

  • The therapeutic landscape for advanced renal cell carcinoma is rapidly evolving with new molecularly targeted agents and immunotherapies.
  • While significant progress has been made, treatment resistance remains a critical challenge.
  • Future strategies are expected to further refine treatment options for metastatic renal cell carcinoma.
Keywords:
ImmunotherapyRenal cell carcinomaTargeted therapy

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