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[Neuroendocrine changes in the climacteric].

J Huber1, E Vytiska-Binstorfer, M Kafka

  • 1I. Universitäts-Frauenklinik Wien.

Wiener Medizinische Wochenschrift (1946)
|August 31, 1987
PubMed
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Hot flushes in menopause are not caused by gonadotropins. Neurotransmitters, specifically vasoactive intestinal peptide (VIP), may play a role in menopausal flushing, warranting further investigation.

Area of Science:

  • Reproductive Endocrinology
  • Neuroendocrinology
  • Menopause Research

Background:

  • Hot flushes are a common symptom of menopause, significantly impacting quality of life.
  • The precise physiological mechanisms underlying hot flushes remain incompletely understood.
  • Previous hypotheses have implicated hormonal fluctuations, particularly gonadotropins.

Purpose of the Study:

  • To investigate the potential role of gonadotropins in the generation of hot flushes.
  • To explore the involvement of neurotransmitters, such as vasoactive intestinal peptide (VIP), in menopausal flushing.

Main Methods:

  • Pharmacological hypophysectomy was induced using Gonadotropin-releasing hormone (GnRH) analogue.
  • Serum gonadotropin levels were monitored.

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  • Vasoactive intestinal peptide (VIP) serum levels were determined during a thyrotropin-releasing hormone (TRH) test.

    • Main Results:

    • Normalization of serum gonadotropin levels was achieved, but hot flushes persisted in all participants.
    • Elevated VIP serum levels were observed in a subset of menopausal women undergoing the TRH test.
    • No direct correlation was found between normalized gonadotropin levels and the cessation of hot flushes.

    Conclusions:

    • Gonadotropins are unlikely to be the primary drivers of hot flushes.
    • Neurotransmitters, potentially VIP, are implicated in the pathophysiology of menopausal flushing.
    • Further research with larger cohorts is necessary to confirm the role of VIP in the climacterium.